Ischemic heart disease, as an example, is a narrowing of the arteries which means less blood and oxygen reaching the heart muscles.
If someone has betrayed you, and your heart literally shuts it self down as a form of protective mechanism, shielding from the pain of betrayal (natural of course), and continues to remain that way without a form of release, a form of forgiveness (not natural), the heart remains with constricted, choked levels of blood supply to your heart.
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